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Two alternatively spliced exons (exons 11A and 12) are utilised exclusively in striated muscle. A comparison in the genomic organization of dystrophin and dystrobrevin confirmed which the 2 genes have sizeable similarities of their genomic construction, implying an ancestral or evolutionary romantic relationship.
the biggest ORF during the dystrobrevin gene demonstrates 50% homology to the cysteine-rich and C-terminal domains of dystrophin, and 84% homology to your phosphoprotein located in the electrical organ postsynaptic membrane in Torpedo californica. Five distinctive mRNA transcripts were preferentially expressed in various tissues.
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Dtna and syncoilin colocalized within the neuromuscular junction of skeletal muscle. Newey et al. (2001) concluded that DTNA delivers a website link in between dystrophin protein intricate plus the intermediate filament community on the neuromuscular junction.
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For discussion of the attainable association amongst variation while in the DTNA gene and susceptibility to Meniere illness, see 156000.
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